Depression is often seen as purely a mood disorder. But a large recent study shows it causes deep changes in brain biology, particularly in the brain's ability to generate new neurons. These findings shed new light on the connection between depression, memory, and chronic pain.
What the Researchers Found
The hippocampus is a key brain region involved in forming memories and in helping us distinguish new experiences from old painful ones. In adults with depression, researchers observed a significant disruption in neurogenesis, that is, the production of new neurons in this area.
In practical terms, when this mechanism is weakened, the brain struggles to "sort" experiences. An old pain can then blend with a present sensation, amplifying suffering and making it harder to move out of a painful or depressive state.
The researchers also identified broad molecular changes that could one day allow treatments to be better tailored to each person's biological profile of depression.
The Real Link Between Depression and Chronic Pain
In my practice in Tel Aviv, I regularly see patients dealing with both physical pain and emotional exhaustion. This is not a coincidence.
Several mechanisms explain this connection:
- A depressed brain processes pain signals in an amplified way
- Disruption of the hippocampus makes painful memories more intrusive
- Depression raises inflammatory markers, which in turn sensitise tissues to pain
- The autonomic nervous system, already strained by chronic stress, loses its flexibility
This creates a cycle that can sustain itself: the more one suffers, the more likely depressive symptoms become, and vice versa.
What Osteopathy Can Offer in This Context
Osteopathy does not treat depression directly. But it acts on several of the mechanisms that link emotional state and physical pain.
By working on the autonomic nervous system through craniosacral techniques or gentle mobilisations, I aim to help the body move out of a state of chronic tension. This can:
- Reduce the overall perception of pain
- Promote better sleep, which is itself essential for neurogenesis
- Ease muscle tension related to stress
- Provide a sense of physical safety, which is often deeply valuable during emotionally vulnerable periods
Of course, osteopathic care works best alongside psychological or psychiatric support when that is needed. I regularly work in connection with other practitioners to offer coherent, joined-up care.
What You Can Do Starting Today
If you are going through a difficult emotional period and are also experiencing persistent physical pain, it is important not to separate the two.
A few simple steps can support neurogenesis and overall wellbeing:
- Move regularly: even gentle exercise stimulates the production of new neurons in the hippocampus
- Sleep enough: sleep is when the brain consolidates and repairs itself
- Reduce inflammation: a diet rich in omega-3s and fibre can help
- Seek support: a mental health professional, an osteopath, your GP, you do not have to manage this alone
If you would like to talk this through during a consultation in Tel Aviv, I am here to support you, at your own pace, taking your full history into account.
